Microtubules: 50 years on from the discovery of tubulin

Nat Rev Mol Cell Biol. 2016 Apr 22;17(5):322-8. doi: 10.1038/nrm.2016.45.


Next year will be the 50th anniversary of the discovery of tubulin. To celebrate this discovery, six leaders in the field of microtubule research reflect on key findings and technological breakthroughs over the past five decades, discuss implications for therapeutic applications and provide their thoughts on what questions need to be addressed in the near future.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Cell Biology / history
  • History, 20th Century
  • Humans
  • Microtubules / physiology*
  • Neoplasms / drug therapy
  • Tubulin / history
  • Tubulin / physiology*
  • Tubulin Modulators / pharmacology
  • Tubulin Modulators / therapeutic use


  • Tubulin
  • Tubulin Modulators