Interleukin-12 (-1188) A/C and interferon-γ (+874) A/T gene polymorphisms in subacute sclerosing panencephalitis patients

J Neurovirol. 2016 Oct;22(5):661-665. doi: 10.1007/s13365-016-0442-7. Epub 2016 Apr 21.

Abstract

The two polymorphisms [IL-12 (-1188) A/C and the IFN-γ (+874) A/T)] are known to have functional consequences and henceforth were analyzed in subacute sclerosing panencephalitis (SSPE) patients to reveal a possible relation with these polymorphisms and this debilitating disease. For the IL-12 (-1188) A/C polymorphism, 78 patients and 90 healthy individuals were analyzed. An increase in the AA genotype was determined (p = 0.02, OR = 2.06). There was also a statistically significant difference between the control group and the patients with respect to the allele frequencies (p = 0.04, OR = 1.65). For the IFN-γ (+874) A/T polymorphism, 69 SSPE patients and 115 controls were studied and there was not a significant difference between the two groups. Our findings suggested that not the IFN-γ (+874) A/T but the IL-12 (-1188) A/C polymorphism is correlated with SSPE and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.

Keywords: Gene polymorphism; IFN-γ; IL-12; SSPE; Subacute sclerosing panencephalitis.

MeSH terms

  • Alleles
  • Case-Control Studies
  • Gene Expression
  • Gene Frequency
  • Genotype*
  • Humans
  • Interferon-gamma / genetics*
  • Interferon-gamma / immunology
  • Interleukin-12 / genetics*
  • Interleukin-12 / immunology
  • Measles virus / immunology
  • Measles virus / pathogenicity*
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic
  • Protective Factors
  • Subacute Sclerosing Panencephalitis / genetics*
  • Subacute Sclerosing Panencephalitis / immunology
  • Subacute Sclerosing Panencephalitis / pathology
  • Subacute Sclerosing Panencephalitis / virology

Substances

  • IFNG protein, human
  • Interleukin-12
  • Interferon-gamma