Brief Report: Seroprevalence of Pertussis Infection in HIV-Infected Adults in the United States

J Acquir Immune Defic Syndr. 2016 Nov 1;73(3):282-286. doi: 10.1097/QAI.0000000000001037.


Pertussis is a resurgent infection that can cause significant morbidity among adults. CD4 T cells are necessary for its clearance, but pertussis studies in HIV-infected adults are limited to case reports. We analyzed stored serum samples from 299 HIV-infected adults to determine the seroprevalence of pertussis among this population. We found that 4.3% of subjects had serologic evidence of recent pertussis infection, and annual incidence of pertussis infection among subjects not vaccinated against pertussis in the last 5 years was 10.5%-17.5%. Prospective studies are needed to define the clinical presentation of pertussis in HIV-infected adults and to optimize vaccination strategies.

MeSH terms

  • AIDS-Related Opportunistic Infections / epidemiology*
  • AIDS-Related Opportunistic Infections / immunology
  • AIDS-Related Opportunistic Infections / microbiology
  • Adult
  • Antibodies, Bacterial / analysis
  • Antibodies, Bacterial / immunology
  • Bordetella pertussis / immunology*
  • CD4 Lymphocyte Count
  • Cross-Sectional Studies
  • HIV Infections / epidemiology*
  • HIV Infections / immunology
  • HIV Infections / microbiology
  • Humans
  • Prevalence
  • Seroepidemiologic Studies
  • United States / epidemiology
  • Whooping Cough / epidemiology*
  • Whooping Cough / immunology
  • Whooping Cough / microbiology


  • Antibodies, Bacterial