Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements

Diana C Cox; Thomas A Cooper

doi:10.1016/j.molcel.2016.04.004

Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements

Mol Cell. 2016 Apr 21;62(2):155-156. doi: 10.1016/j.molcel.2016.04.004.

Authors

Diana C Cox¹, Thomas A Cooper²

Affiliations

¹ Departments of Pathology and Immunology, Molecular and Cellular Biology, and Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
² Departments of Pathology and Immunology, Molecular and Cellular Biology, and Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: tcooper@bcm.edu.

PMID: 27105111
DOI: 10.1016/j.molcel.2016.04.004

Abstract

Repeat expansions cause dominantly inherited neurological disorders. In this issue of Molecular Cell, Kearse et al. (2016) examine the requirements for RAN translation of the CGG repeats that cause fragile X-associated tremor/ataxia syndrome, revealing similarities and differences with canonical translation.

Publication types

Comment

MeSH terms

Ataxia*
Fragile X Mental Retardation Protein
Fragile X Syndrome*
Humans
Tremor

Substances

Fragile X Mental Retardation Protein

Abstract

Publication types

MeSH terms

Substances

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