SL2: an interactive webtool for modeling of missing segments in proteins

Nucleic Acids Res. 2016 Jul 8;44(W1):W390-4. doi: 10.1093/nar/gkw297. Epub 2016 Apr 21.


SuperLooper2 (SL2) ( is the updated version of our previous web-server SuperLooper, a fragment based tool for the prediction and interactive placement of loop structures into globular and helical membrane proteins. In comparison to our previous version, SL2 benefits from both a considerably enlarged database of fragments derived from high-resolution 3D protein structures of globular and helical membrane proteins, and the integration of a new protein viewer. The database, now with double the content, significantly improved the coverage of fragment conformations and prediction quality. The employment of the NGL viewer for visualization of the protein under investigation and interactive selection of appropriate loops makes SL2 independent of third-party plug-ins and additional installations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Protein
  • Internet*
  • Models, Molecular*
  • Peptide Fragments / chemistry*
  • Protein Conformation
  • Proteins / chemistry*
  • Software*
  • User-Computer Interface


  • Peptide Fragments
  • Proteins