Notch in fibrosis and as a target of anti-fibrotic therapy

Pharmacol Res. 2016 Jun;108:57-64. doi: 10.1016/j.phrs.2016.04.010. Epub 2016 Apr 21.

Abstract

The Notch pathway represents a highly conserved signaling network with essential roles in regulation of key cellular processes and functions, many of which are critical for development. Accumulating evidence indicates that it is also essential for fibrosis and thus the pathogenesis of chronic fibroproliferative diseases in diverse organs and tissues. Different effects of Notch activation are observed depending on cellular and tissue context as well as in both physiologic and pathologic states. Close interactions of Notch signaling pathway with other signaling pathways have been identified. In this review, current knowledge on the role of the Notch signaling with special focus on fibrosis and its potential as a therapeutic target is summarized.

Keywords: Fibrosis; Myofibroblast; Notch.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Proliferation
  • Epithelial-Mesenchymal Transition
  • Fibrosis
  • Humans
  • Kidney / metabolism
  • Kidney / pathology
  • Liver / metabolism
  • Liver / pathology
  • Liver Cirrhosis / metabolism
  • Liver Cirrhosis / pathology*
  • Lung / metabolism
  • Lung / pathology
  • Myofibroblasts / metabolism
  • Myofibroblasts / pathology
  • Pulmonary Fibrosis / metabolism
  • Pulmonary Fibrosis / pathology*
  • Receptors, Notch / analysis
  • Receptors, Notch / metabolism*
  • Renal Insufficiency, Chronic / metabolism
  • Renal Insufficiency, Chronic / pathology*
  • Signal Transduction*
  • Skin / metabolism
  • Skin / pathology*

Substances

  • Receptors, Notch