Changes in respiratory function in Pembroke Welsh Corgi dogs with degenerative myelopathy

J Vet Med Sci. 2016 Sep 1;78(8):1323-7. doi: 10.1292/jvms.15-0521. Epub 2016 Apr 24.

Abstract

Canine degenerative myelopathy (DM) is characterized by progressive degeneration of the spinal cord. Although atrophic changes in the intercostal muscles were previously reported in the late stage of DM in Pembroke Welsh Corgis (PWCs), changes in respiratory function have not yet been examined. In the present study, we performed an arterial blood gas analysis and measured respiratory movements over progressive disease stages to document changes in respiratory function in DM-affected PWCs. We found that respiratory dysfunction progressed during the later stages of DM and correlated with a change in respiratory movement to the abdominal breathing pattern. These results suggested that hypoventilation occurred due to dysfunctional changes in the intercostal muscles and resulted in hypoxemia in the later stages of DM.

MeSH terms

  • Animals
  • Blood Gas Analysis / veterinary
  • Disease Progression
  • Dog Diseases / physiopathology*
  • Dogs
  • Male
  • Neurodegenerative Diseases / physiopathology
  • Neurodegenerative Diseases / veterinary*
  • Respiration
  • Respiratory Physiological Phenomena*
  • Spinal Cord Diseases / physiopathology
  • Spinal Cord Diseases / veterinary*