Elevated Diastolic Closing Margin Is Associated with Intraventricular Hemorrhage in Premature Infants

J Pediatr. 2016 Jul;174:52-6. doi: 10.1016/j.jpeds.2016.03.066. Epub 2016 Apr 23.


Objective: To determine whether the diastolic closing margin (DCM), defined as diastolic blood pressure minus critical closing pressure, is associated with the development of early severe intraventricular hemorrhage (IVH).

Study design: A reanalysis of prospectively collected data was conducted. Premature infants (gestational age 23-31 weeks) receiving mechanical ventilation (n = 185) had ∼1-hour continuous recordings of umbilical arterial blood pressure, middle cerebral artery cerebral blood flow velocity, and PaCO2 during the first week of life. Models using multivariate generalized linear regression and purposeful selection were used to determine associations with severe IVH.

Results: Severe IVH (grades 3-4) was observed in 14.6% of the infants. Irrespective of the model used, Apgar score at 5 minutes and DCM were significantly associated with severe IVH. A clinically relevant 5-mm Hg increase in DCM was associated with a 1.83- to 1.89-fold increased odds of developing severe IVH.

Conclusion: Elevated DCM was associated with severe IVH, consistent with previous animal data showing that IVH is associated with hyperperfusion. Measurement of DCM may be more useful than blood pressure in defining cerebral perfusion in premature infants.

Keywords: arterial blood pressure; cerebral blood flow; critical closing pressure.

MeSH terms

  • Blood Flow Velocity / physiology
  • Blood Pressure / physiology*
  • Cerebral Hemorrhage / etiology*
  • Cerebral Hemorrhage / physiopathology*
  • Cohort Studies
  • Diastole
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / etiology*
  • Infant, Premature, Diseases / physiopathology*
  • Male
  • Middle Cerebral Artery / physiology
  • Respiration, Artificial
  • Umbilical Arteries / physiology