Blood component modifications can be performed by the hospital blood bank for select clinical indications. In general, modification of blood components increases costs and may delay availability of the blood component because of the additional time required for some modification steps. However, the benefit of blood product modification may outweigh these concerns. Common modifications include leukoreduction, irradiation, volume reduction, splitting, and washing. Modification availability and selection practice may vary from hospital to hospital. In this article, available blood component modifications are described along with the benefits, drawbacks, and specific clinical indications supporting their use.
Keywords: Blood banking; Platelets; Red blood cells; Transfusion medicine; Transfusion reactions.
Copyright © 2016 Elsevier Inc. All rights reserved.