Development of Tract-Specific White Matter Pathways During Early Reading Development in At-Risk Children and Typical Controls

Cereb Cortex. 2017 Apr 1;27(4):2469-2485. doi: 10.1093/cercor/bhw095.

Abstract

Developmental dyslexia is a neurodevelopmental disorder with a strong genetic basis. Previous studies observed white matter alterations in the left posterior brain regions in adults and school-age children with dyslexia. However, no study yet has examined the development of tract-specific white matter pathways from the pre-reading to the fluent reading stage in children at familial risk for dyslexia (FHD+) versus controls (FHD-). This study examined white matter integrity at pre-reading, beginning, and fluent reading stages cross-sectionally ( n = 78) and longitudinally (n = 45) using an automated fiber-tract quantification method. Our findings depict white matter alterations and atypical lateralization of the arcuate fasciculus at the pre-reading stage in FHD+ versus FHD- children. Moreover, we demonstrate faster white matter development in subsequent good versus poor readers and a positive association between white matter maturation and reading development using a longitudinal design. Additionally, the combination of white matter maturation, familial risk, and psychometric measures best predicted later reading abilities. Furthermore, within FHD+ children, subsequent good readers exhibited faster white matter development in the right superior longitudinal fasciculus compared with subsequent poor readers, suggesting a compensatory mechanism. Overall, our findings highlight the importance of white matter pathway maturation in the development of typical and atypical reading skills.

Keywords: developmental dyslexia; familial risk; longitudinal; tractography; white matter development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Brain / pathology*
  • Brain Mapping
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Diffusion Tensor Imaging
  • Dyslexia / pathology*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Image Interpretation, Computer-Assisted
  • Male
  • Neural Pathways / pathology*
  • Reading
  • White Matter / pathology*