Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability

Attila Toth; Rolf Jessberger

doi:10.1016/j.cub.2016.02.059

Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability

Curr Biol. 2016 Apr 25;26(8):R329-31. doi: 10.1016/j.cub.2016.02.059.

Authors

Attila Toth¹, Rolf Jessberger²

Affiliations

¹ Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01326 Dresden, Germany.
² Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01326 Dresden, Germany. Electronic address: Rolf.Jessberger@tu-dresden.de.

PMID: 27115691
DOI: 10.1016/j.cub.2016.02.059

Abstract

Meiotic chromosome segregation in mouse oocytes seems to rely on highly stable cohesins and CENP-A produced in the fetus and not replenished during postnatal life. Hence, demise of these proteins may underpin declining oocyte quality in ageing mammals and thus marks a major problem of reproductive health in humans.

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MeSH terms

Aging*
Animals
Chromosomes
Humans
Meiosis*
Mice
Oocytes
Oogenesis
Protein Stability