Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability

Curr Biol. 2016 Apr 25;26(8):R329-31. doi: 10.1016/j.cub.2016.02.059.


Meiotic chromosome segregation in mouse oocytes seems to rely on highly stable cohesins and CENP-A produced in the fetus and not replenished during postnatal life. Hence, demise of these proteins may underpin declining oocyte quality in ageing mammals and thus marks a major problem of reproductive health in humans.

Publication types

  • Comment

MeSH terms

  • Aging*
  • Animals
  • Chromosomes
  • Humans
  • Meiosis*
  • Mice
  • Oocytes
  • Oogenesis
  • Protein Stability