Prolonged effects of miconazole oral gel on warfarin anticoagulation even after treatment withdrawal

Int J Clin Pharmacol Ther. 2016 Jun;54(6):474-6. doi: 10.5414/CP202597.

Abstract

Objective: We investigated the effect of terminating miconazole oral gel (MOG) treatment on the anticoagulant activity of warfarin by evaluating changes in international normalized ratio levels (INR).

Methods: Data were collected from the medical records of 6 patients treated with warfarin and MOG.

Results: Following cessation of MOG treatment, increased INR and INR/dose levels were observed for an average of 15 days, showing that the anticoagulant activity of warfarin was increased for ~ 2 weeks.

Conclusions: Closer monitoring of INR levels for at least 2 weeks may be required upon withdrawal of MOG treatment in patients treated with warfarin.

MeSH terms

  • Administration, Oral
  • Aged
  • Aged, 80 and over
  • Anticoagulants / pharmacology*
  • Female
  • Gels
  • Humans
  • International Normalized Ratio
  • Male
  • Miconazole / pharmacology*
  • Middle Aged
  • Warfarin / pharmacology*

Substances

  • Anticoagulants
  • Gels
  • Warfarin
  • Miconazole