Chronic cerebrovascular dysfunction after traumatic brain injury

J Neurosci Res. 2016 Jul;94(7):609-22. doi: 10.1002/jnr.23732. Epub 2016 Apr 27.


Traumatic brain injuries (TBI) often involve vascular dysfunction that leads to long-term alterations in physiological and cognitive functions of the brain. Indeed, all the cells that form blood vessels and that are involved in maintaining their proper function can be altered by TBI. This Review focuses on the different types of cerebrovascular dysfunction that occur after TBI, including cerebral blood flow alterations, autoregulation impairments, subarachnoid hemorrhage, vasospasms, blood-brain barrier disruption, and edema formation. We also discuss the mechanisms that mediate these dysfunctions, focusing on the cellular components of cerebral blood vessels (endothelial cells, smooth muscle cells, astrocytes, pericytes, perivascular nerves) and their known and potential roles in the secondary injury cascade. © 2016 Wiley Periodicals, Inc.

Keywords: cerebrovascular dysfunction; neurovascular dysfunction; traumatic brain injury.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood-Brain Barrier / physiopathology
  • Brain Injuries, Traumatic / complications*
  • Brain Injuries, Traumatic / physiopathology
  • Cerebrovascular Circulation
  • Cerebrovascular Disorders / etiology*
  • Chronic Disease
  • Humans