The emergence and evolution of antimicrobial resistance: Impact on a global scale

Bioorg Med Chem. 2016 Dec 15;24(24):6440-6445. doi: 10.1016/j.bmc.2016.04.027. Epub 2016 Apr 13.


The evolution of antimicrobial resistance is a multifaceted issue that is influenced by numerous factors. This growing healthcare problem has significantly impacted the public welfare and has substantially burdened the economic system on a global scale. In an effort to combat this rising problem, several strategies have been implemented in the recent years to stall the progression and decrease the emergence of antimicrobial resistance. The aim of this review article is to describe the various factors that have contributed to the current state of antimicrobial resistance and to evaluate potential strategies developed to reduce the burden of antimicrobial resistance.

Keywords: Antibiotic; Antimicrobial; Resistance.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects*
  • Drug Resistance, Bacterial / drug effects*
  • Humans


  • Anti-Bacterial Agents