Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption

Eur J Clin Nutr. 2016 Sep;70(9):1000-3. doi: 10.1038/ejcn.2016.66. Epub 2016 Apr 27.


Background/objectives: Primary adult-type lactose malabsorption (PALM) is a widespread inherited autosomal recessive condition, which is considered to be associated with osteoporosis. This prospective study aimed at assessing the 25-hydroxy-vitamin D (25(OH)D) status and serum CrossLaps levels in individuals with PALM and normal controls.

Subjects/methods: All participants (n=210) underwent genotyping for the LCT C/T-13910 polymorphism, 25(OH)D and CrossLaps measurements and clinical examinations. In addition, the anthropometric data (that is, height, weight and body mass index) were determined.

Results: Fifty-five individuals with PALM (that is, LCT C/C-13910 homozygotes) showed lower 25(OH)D (mean: 24.95±10.04 vs 28.59±9.56 ng/ml, P=0.018) and higher CrossLaps serum levels (mean: 0.46±0.31 vs 0.43±0.49 ng/ml, P=0.251) compared with 155 normal controls (that is, LCT C/T-13910 hetero- or T/T-13910 homozygotes). Anthropometric data were similar between PALM probands and controls.

Conclusions: Individuals with PALM were found to have lower 25(OH)D and higher CrossLaps serum levels compared with normal controls. In order to preserve life-long bone health, routine 25(OH)D and CrossLaps serum measurements should be performed in individuals with PALM.

MeSH terms

  • Adult
  • Body Mass Index
  • Collagen / blood*
  • Collagen Type I / blood*
  • Female
  • Genotype
  • Humans
  • Intestinal Absorption*
  • Lactase / blood
  • Lactase / deficiency*
  • Lactase / genetics
  • Lactase / metabolism
  • Lactose / metabolism*
  • Lactose Intolerance / blood
  • Lactose Intolerance / complications*
  • Lactose Intolerance / genetics
  • Male
  • Middle Aged
  • Osteoporosis / etiology
  • Osteoporosis / genetics
  • Peptide Fragments / blood*
  • Peptides / blood*
  • Polymorphism, Single Nucleotide
  • Prospective Studies
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / complications*
  • Vitamins / blood
  • Young Adult


  • Collagen Type I
  • Peptide Fragments
  • Peptides
  • Vitamins
  • collagen type I trimeric cross-linked peptide
  • glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine
  • Vitamin D
  • Collagen
  • 25-hydroxyvitamin D
  • Lactase
  • Lactose

Supplementary concepts

  • Lactose Intolerance, Adult Type