The past 20 years of mobile technology has shifted the ways in which young people communicate and network with one another. Mobile phone use is prevalent among adolescents and therefore is an ideal form of communication for tailored health care. This is especially so given the dramatic uptake in use of mobile technologies in this age group. Technology developments have also altered how physicians and public health interventionists communicate with adolescents for prevention messages. Rapidly changing technology has made the study of how best to communicate with youth a challenge because research can scarcely keep up with advances in the technology. However, best practices from behavior change and communication theories remain a foundation for future intervention directions and how we might best meet the health promotion needs of adolescents.