Lateralization of dementia of depression in stroke patients

Am J Psychiatry. 1989 May;146(5):627-34. doi: 10.1176/ajp.146.5.627.


In a group of stroke patients with left-hemisphere lesions, those with major depression performed significantly below nondepressed patients on four of nine cognitive domains examined with a neuropsychological test battery. Among patients with right-hemisphere stroke, those with major depression did not perform below nondepressed patients on any of the nine cognitive domains. The differential effect of depression on cognitive performance between left- and right-hemisphere lesion groups could not be accounted for by demographic variables, neurological symptoms, lesion location, or lesion size. Poststroke major depression appeared to produce a decline in cognitive performance or dementia of depression that depended on the laterality of the lesion.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain / physiopathology
  • Cerebrovascular Disorders / complications*
  • Dementia / diagnosis*
  • Dementia / etiology
  • Dementia / physiopathology
  • Depressive Disorder / diagnosis*
  • Depressive Disorder / etiology
  • Depressive Disorder / physiopathology
  • Female
  • Functional Laterality* / physiology
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests*
  • Tomography, X-Ray Computed