Topiramate for Treatment in Patients With Migraine and Epilepsy

Headache. 2016 Jun;56(6):1081-5. doi: 10.1111/head.12826. Epub 2016 Apr 28.


Background: Antiepileptic drugs (AED) are often considered first line for monotherapy in treatment of patients with migraines, and also those with comorbid migraine and epilepsy. Topiramate, a newer generation AED, has broad mechanism of action and evidence of benefit in patients with either episodic or chronic migraine along with epilepsy, both generalized and focal.

Methods: Our goal is to review the relevant mechanisms of action along with any supportive evidence published to date on the use of topiramate (TPM) in patients with both migraine headache and epilepsy.

Conclusions: There has been very little published to date on the use of TPM in patients diagnosed with both disorders. Despite this, TPM has been adopted as first line therapy in this patient population. Future studies investigating the effectiveness of this treatment strategy are warranted in order to determine the most effective use of this medication in patients diagnosed with migraine headaches and epilepsy.

Keywords: antiepileptic drugs; chronic migraine; epilepsy; topiramate.

Publication types

  • Review

MeSH terms

  • Databases, Bibliographic / statistics & numerical data
  • Epilepsy / complications
  • Epilepsy / drug therapy*
  • Female
  • Fructose / analogs & derivatives*
  • Fructose / therapeutic use
  • Humans
  • Male
  • Migraine Disorders / complications
  • Migraine Disorders / prevention & control*
  • Neuroprotective Agents / therapeutic use*
  • Topiramate


  • Neuroprotective Agents
  • Topiramate
  • Fructose