Chemotherapy-induced Painful Acral Erythema in Childhood: Burgdorf's Reaction

Am J Pediatr Hematol Oncol. Spring 1989;11(1):44-5. doi: 10.1097/00043426-198921000-00011.


Painful acral erythema as a reaction to intensive chemotherapy has been increasingly recognized since 1982. It has not been reported in the pediatric literature. We report its occurrence in a 3-year-old boy who had received intensive chemotherapy for acute lymphoblastic leukemia.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Child, Preschool
  • Erythema / chemically induced*
  • Humans
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy


  • Antineoplastic Agents