Synthesis of isotopically labelled 2-isopropylthioxanthone from 2,2'-dithiosalicylic acid and deuterium cumene

J Labelled Comp Radiopharm. 2016 Jun 30;59(8):313-6. doi: 10.1002/jlcr.3400. Epub 2016 Apr 28.

Abstract

Two efficient synthetic routes of stable deuterium labelled 2-isopropylthioxanthone were presented with 98.1% and 98.8% isotopic abundance in acceptable yields and excellent chemical purities. Their structures and the isotope-abundance were confirmed according to proton nuclear magnetic resonance and liquid chromatography-mass spectrometry.

Keywords: 2-isopropylthioxanthone; deuterium cumene; labelled internal standards; two synthetic routes.

MeSH terms

  • Benzene Derivatives / chemistry*
  • Chemistry Techniques, Synthetic
  • Deuterium / chemistry*
  • Isotope Labeling
  • Radiochemistry
  • Salicylates / chemistry*
  • Xanthones / chemical synthesis*
  • Xanthones / chemistry*

Substances

  • Benzene Derivatives
  • Salicylates
  • Xanthones
  • isopropyl thioxanthone
  • dithiosalicylic acid
  • cumene
  • Deuterium