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Review
. 2016 Jul;16(7):849-59.
doi: 10.1080/14737175.2016.1184088. Epub 2016 May 17.

Anti N-methyl-D-aspartate Receptor Encephalitis: A Game-Changer?

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Review

Anti N-methyl-D-aspartate Receptor Encephalitis: A Game-Changer?

Corinne E Fischer et al. Expert Rev Neurother. .

Abstract

Introduction: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an inflammatory disorder of the brain that has garnered significant interest within the medical and lay communities. There is a need for formal guidelines to assist physicians in identifying patients who should undergo testing for NMDAR encephalitis, recognizing the high potential for this potentially treatable disease to mimic more common disorders, and consequently remain undiagnosed.

Areas covered: This review highlights the impact of the discovery of NMDAR encephalitis on the fields of neurology and psychiatry, and discusses the steps that are necessary to improve recognition and treatment of NMDAR encephalitis. Expert commentary: While much progress has been made in our understanding of NMDAR encephalitis, much work remains to be done to delineate the underlying disease mechanisms and their relevance to brain function.

Keywords: NMDA receptor; delusions; encephalitis; hallucinations; psychosis.

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