Reduction-Responsive Guanine Incorporated into G-Quadruplex-Forming DNA

Chembiochem. 2016 Jul 15;17(14):1304-7. doi: 10.1002/cbic.201600164. Epub 2016 May 24.


Stimulus-responsive biomolecules are attractive targets to understand biomolecule behaviour as well as to explore their therapeutic and diagnostic applications. We demonstrate that a reduction-responsive cleavable group (chemically caged unit) introduced into the guanine ring enables modulation of the secondary structure transition of an oligonucleotide in a reduction-responsive and traceless manner leaving the unmodified oligonucleotide of interest. This simple but robust strategy could yield a variety of stimuli-responsive oligonucleotides.

Keywords: DNA structures; G-quadruplexes; cleavage reactions; conjugation; stimuli-responsive.

Publication types

  • Review

MeSH terms

  • DNA / chemistry
  • G-Quadruplexes*
  • Guanine / chemistry*
  • Nucleic Acid Conformation
  • Oligonucleotides / chemistry*
  • Oxidation-Reduction


  • Oligonucleotides
  • Guanine
  • DNA