Borderline ankle-brachial index is associated with poor short-term clinical outcome after coronary artery intervention

Atherosclerosis. 2016 Jun;249:186-90. doi: 10.1016/j.atherosclerosis.2016.03.027. Epub 2016 Mar 28.

Abstract

Objective: To evaluate the association between borderline ankle-brachial index (ABI) and clinical outcome in patients who underwent percutaneous coronary intervention (PCI).

Methods: From August 2009 to August 2012, ABI was measured in 1291 patients who underwent PCI. Patients with borderline ABI were compared with those who had normal ABI. The primary outcome was major adverse cardiac and cerebrovascular event (MACCE), defined as a composite of all-cause death, myocardial infarction, stroke, and repeat revascularization.

Results: Of the 1291 patients, 1154 (82%) had normal ABI and 89 (7%) had borderline ABI. The median overall follow-up duration was 19 (interquartile range 13-26) months. After adjustment with IPTW, the incidence of stroke (HR, 6.28; CI 95%, 1.95-20.19; P < 0.01) and MACCE (HR, 2.54; CI 95%, 1.40-4.62; P < 0.01) were higher in the borderline ABI group. In a propensity score-matched population, the incidence of stroke (HR, 4.68; CI 95%, 1.18-18.52; p = 0.03) and MACCE (HR, 2.12; CI 95%, 1.09-4.11; P = 0.03) were still significantly higher.

Conclusion: The presence of borderline ABI was associated with worse clinical outcome and increased stroke rate compared with normal ABI during the short-term follow-up period in patients who underwent coronary intervention.

Keywords: Borderline ankle-brachial index; Coronary artery disease; Percutaneous coronary intervention.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Ankle Brachial Index*
  • Biomarkers / metabolism
  • C-Reactive Protein / metabolism
  • Coronary Artery Disease / complications
  • Coronary Artery Disease / therapy*
  • Coronary Vessels / physiopathology*
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Myocardial Infarction / complications
  • Myocardial Infarction / therapy
  • Percutaneous Coronary Intervention / adverse effects*
  • Percutaneous Coronary Intervention / methods
  • Prospective Studies
  • Risk Factors
  • Stroke / complications
  • Stroke / physiopathology
  • Stroke / therapy
  • Time Factors
  • Treatment Outcome

Substances

  • Biomarkers
  • C-Reactive Protein