[Anti-Inflammatory Activity of the Polypeptide of the Sea Anemone, Heteractis crispa]

O V Sintsova; M M Monastyrnaya; E A Pislyagin; E S Menchinskaya; E V Leychenko; D L Aminin; E P Kozlovskaya

doi:10.1134/s106816201506014x

[Anti-Inflammatory Activity of the Polypeptide of the Sea Anemone, Heteractis crispa]

Bioorg Khim. 2015 Nov-Dec;41(6):657-63. doi: 10.1134/s106816201506014x.

[Article in Russian]

Authors

O V Sintsova, M M Monastyrnaya, E A Pislyagin, E S Menchinskaya, E V Leychenko, D L Aminin, E P Kozlovskaya

PMID: 27125018
DOI: 10.1134/s106816201506014x

Abstract

The anti-inflammatory effect of the recombinant polypeptide HCGS 1.20, a Kunitz-type serine protease inhibitor of the sea anemone Heteractis crispa, was investigated. It was shown that the polypeptide inhibits the increase of the concentration of calcium ions in mouse bone marrow derived macrophages elicited by histamine, and reduces the content of NO in lipopolysaccharide stimulated macrophages. A presumable mechanism of anti-inflammatory action of the polypeptide was being discussed.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents* / chemistry
Anti-Inflammatory Agents* / pharmacology
Cell Line
Histamine / metabolism
Lipopolysaccharides / pharmacology
Macrophages / metabolism*
Macrophages / pathology
Mice
Nitric Oxide / metabolism
Peptides* / chemistry
Peptides* / genetics
Peptides* / pharmacology
Sea Anemones* / chemistry
Sea Anemones* / genetics

Substances

Anti-Inflammatory Agents
Lipopolysaccharides
Peptides
Nitric Oxide
Histamine