Rev Med Chir Soc Med Nat Iasi. 2016 Jan-Mar;120(1):173-7.


Aim: To determine during the first trimester of pregnancy some serum and ultrasound markers that could improve perinatal morbidity and mortality in women with intrauterine growth restriction (IUGR).

Material and methods: Prospective study of pregnant women gestational age 11 weeks and 0 days--13 weeks and 6 days, consisting in the determination of pregnancy associated plasma protein (PAPP-A), mean platelet volume (MPV), and ultrasound appearance of placenta.

Discussion and conclusions: This study suggests that screening by detailed history and PAPP-A and MPV determination during the first trimester of pregnancy in women at risk for IUGR makes possible the prophylactic treatment and monitoring of pregnancy according to a given protocol and thus neonatal morbidity and mortality to be reduced.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Female
  • Fetal Growth Retardation / blood*
  • Fetal Growth Retardation / diagnosis*
  • Fetal Growth Retardation / metabolism
  • Fetal Growth Retardation / prevention & control
  • Humans
  • Mean Platelet Volume*
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Trimester, First
  • Pregnancy-Associated Plasma Protein-A / metabolism*
  • Prenatal Diagnosis
  • Prospective Studies
  • Risk Factors
  • Sensitivity and Specificity
  • Ultrasonography, Prenatal*


  • Biomarkers
  • Pregnancy-Associated Plasma Protein-A
  • PAPPA protein, human