Effect of thyroid autoimmunity per se on assisted reproduction treatment outcomes: A meta-analysis

Taiwan J Obstet Gynecol. 2016 Apr;55(2):159-65. doi: 10.1016/j.tjog.2015.09.003.


Objective: Thyroid autoimmunity (TA) is the most prevalent autoimmune disease in women of reproductive age and is often accompanied by subclinical hypothyroidism (SCH). Both TA and SCH have been associated with adverse pregnancy outcomes, but their relative influence is unclear. Therefore, we carried out a meta-analysis to evaluate the sole effect of TA on pregnancy outcomes in euthyroid women undergoing assisted reproductive technology.

Materials and methods: Literature searches were conducted on Pubmed, EMBASE, and the Cochrane Controlled Trials Register Database from inception to May 2014.

Results: In euthyroid women whose SCH status is unknown, those with positive antithyroid antibodies (ATA) had a higher miscarriage rate [pooled relative risk (RR) = 1.638; 95% confidence interval (CI), 1.228-2.185] and a lower delivery rate (pooled RR = 0.856; 95% CI, 0.759-0.965) than those with negative ATA. Clinical pregnancy rates were similar between groups. However, clinical pregnancy rate, miscarriage rate, and delivery rate were all comparable between ATA-positive and ATA-negative euthyroid women without SCH.

Conclusion: TA per se does not impair assisted reproductive treatment outcomes in women without SCH.

Keywords: assisted reproductive treatment; meta-analysis; pregnancy outcomes; thyroid autoimmunity.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Abortion, Spontaneous
  • Autoantibodies / blood
  • Autoimmune Diseases / blood
  • Autoimmune Diseases / complications*
  • Delivery, Obstetric
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications / blood
  • Pregnancy Complications / immunology*
  • Pregnancy Rate
  • Reproductive Techniques, Assisted*
  • Thyroid Diseases / blood
  • Thyroid Diseases / immunology*
  • Treatment Outcome


  • Autoantibodies