Klotho Prevents Translocation of NFκB

Vitam Horm. 2016:101:119-50. doi: 10.1016/bs.vh.2016.02.005. Epub 2016 Mar 16.

Abstract

Klotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating form. This protein is recognized as an antiaging gene with pleiotropic functions. The activation of cellular systems is associated with the pathogenesis of several chronic and degenerative diseases associated with an inflammatory state. Inflammation is characterized by an activation of NFκB. Klotho suppresses nuclear factor NFκB activation and the subsequent transcription of proinflammatory genes. This review focuses on the current understanding of Klotho protein function and its relationship with NFκB regulation, emphasizing its potential involvement in the pathophysiologic process.

Keywords: Chronic kidney disease; FGF-23; Inflammation; Klotho; NFκB; Oxidative stress; Senescence.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases
  • Cellular Senescence / physiology
  • Diabetes Mellitus
  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors / metabolism
  • Forkhead Box Protein O1 / genetics
  • Glucuronidase / chemistry
  • Glucuronidase / metabolism
  • Glucuronidase / physiology*
  • Hormones
  • Humans
  • Inflammation / physiopathology
  • Insulin / metabolism
  • Klotho Proteins
  • NF-kappa B / metabolism*
  • Pulmonary Disease, Chronic Obstructive
  • Receptors, Fibroblast Growth Factor
  • Renal Insufficiency, Chronic
  • Signal Transduction / physiology

Substances

  • FGF23 protein, human
  • FOXO1 protein, human
  • Forkhead Box Protein O1
  • Hormones
  • Insulin
  • NF-kappa B
  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Glucuronidase
  • Klotho Proteins