Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces

Adv Healthc Mater. 2016 Aug;5(15):1861-7. doi: 10.1002/adhm.201600295. Epub 2016 Apr 29.


Engineering interfaces of distinct extracellular compartments mimicking native tissues are key for in-depth in vitro studies on developmental and disease processes in biology and medicine. Sharp interfaces of extracellular matrices are constructed based on fibrillar collagen I networks with a multiparameter control of topology, mechanics, and composition, and their distinct impact on triggering the directionality of cancer cell migration is demonstrated.

Keywords: biomaterials; biopolymer networks; cancer cell migration; matrix engineering; matrix interfaces.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetic Materials / chemistry*
  • Cell Line, Tumor
  • Cell Movement*
  • Collagen Type I / chemistry*
  • Extracellular Matrix / chemistry*
  • Female
  • Humans


  • Collagen Type I