Potential use of SERS-assisted theranostic strategy based on Fe3O4/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia

Yu Han; Sheng-Lan Lei; Jian-Hua Lu; Yuan He; Zhi-Wei Chen; Lei Ren; Xi Zhou

doi:10.1016/j.msec.2016.03.090

Potential use of SERS-assisted theranostic strategy based on Fe3O4/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia

Mater Sci Eng C Mater Biol Appl. 2016 Jul 1:64:199-207. doi: 10.1016/j.msec.2016.03.090. Epub 2016 Mar 24.

Authors

Yu Han¹, Sheng-Lan Lei¹, Jian-Hua Lu², Yuan He¹, Zhi-Wei Chen³, Lei Ren⁴, Xi Zhou⁵

Affiliations

¹ Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
² Department of Electronic Science, College of Physical Science and Technology, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen 361005, People's Republic of China.
³ Department of Electronic Science, College of Physical Science and Technology, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen 361005, People's Republic of China. Electronic address: chenzhiwei@xmu.edu.cn.
⁴ Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China; State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, People's Republic of China; Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen 361005, People's Republic of China. Electronic address: renlei@xmu.edu.cn.
⁵ Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China; Fujian Provincial Key Laboratory of Fire Retardant Materials, Xiamen University, Xiamen 361005, People's Republic of China; Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen 361005, People's Republic of China.

PMID: 27127045
DOI: 10.1016/j.msec.2016.03.090

Abstract

A surface-enhanced Raman scattering (SERS)-assisted theranostic strategy was designed based on a synthesized multifunctional Fe3O4/Au cluster/shell nanocomposite. This theranostic strategy was used for free prostate specific antigen (free-PSA) detection, magnetic resonance imaging (MRI), and magnetic hyperthermia. The lowest protein concentration detected was 1ngmL(-1), and the limit of detection (LOD) of the calculated PSA was 0.75ngmL(-1). Then, MRI was carried out to visualize the tumor cell. Lastly, magnetic hyperthermia was employed and revealed a favorable killing effect for the tumor cells. Thus, this SERS-assisted strategy based on a Fe3O4/Au cluster/shell nanocomposite showed great advantages in theranostic treatment.

Keywords: Fe(3)O(4)@Au nanoparticles; MRI; Magnetic hyperthermia; Multifunction; PSA detection; SERS.

MeSH terms

Cell Line, Tumor
Contrast Media* / chemistry
Contrast Media* / pharmacology
Ferrosoferric Oxide* / chemistry
Ferrosoferric Oxide* / pharmacology
Gold* / chemistry
Gold* / pharmacology
Humans
Hyperthermia, Induced*
Magnetic Field Therapy*
Magnetic Resonance Imaging*
Nanocomposites / chemistry*
Theranostic Nanomedicine*

Substances

Contrast Media
Gold
Ferrosoferric Oxide