Left Ventricular Function Assessment Using 2 Different Cadmium-Zinc-Telluride Cameras Compared with a γ-Camera with Cardiofocal Collimators: Dynamic Cardiac Phantom Study and Clinical Validation

J Nucl Med. 2016 Sep;57(9):1370-5. doi: 10.2967/jnumed.115.168575. Epub 2016 Apr 28.


This study compared two SPECT cameras with cadmium-zinc-telluride (CZT) detectors to a conventional Anger camera with cardiofocal collimators for the assessment of left ventricular (LV) function in a phantom and patients.

Methods: A gated dynamic cardiac phantom was used. Eighteen acquisitions were processed on each CZT camera and the conventional camera. The total number of counts within a myocardial volume of interest varied from 0.25 kcts to 1.5 Mcts. Ejection fraction was set to 33%, 45%, or 60%. Volume, LV ejection fraction (LVEF), regional wall thickening, and motion (17-segment model) were assessed. One hundred twenty patients with a low pretest likelihood of coronary artery disease and normal findings on stress perfusion SPECT were retrospectively analyzed to provide the reference limits for end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction, and regional function for each camera model.

Results: In the phantom study, for each ejection fraction value, volume was higher for the CZT cameras than for the conventional camera, resulting in a decreased but more accurate LVEF (all P < 0.001). In clinical data, body-surface-indexed EDV and ESV (mL/m(2)) were higher for one of the CZT cameras (Discovery NM 530c) than for the other (D-SPECT) or the conventional camera (respectively, 40.5 ± 9.2, 37 ± 7.9, and 35.8 ± 6.8 for EDV [P < 0.001] and 12.5 ± 5.3, 9.4 ± 4.2, and 8.3 ± 4.4 for ESV [P < 0.001]), resulting in a significantly decreased LVEF: 70.3% ± 9.1% vs. 75.2% ± 8.1% vs. 77.8% ± 9.3%, respectively (P < 0.001).

Conclusion: The new CZT cameras yielded global LV function results different from those yielded by the conventional camera. LV volume was higher for the Discovery NM 530c than for the D-SPECT or the conventional camera, leading to decreased LVEF in healthy subjects. These differences should be considered in clinical practice and warrant the collection of a specific reference database.

Keywords: CZT; cardiofocal collimators; dynamic phantom; left ventricular function; myocardial perfusion imaging; wall thickening.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Cadmium Compounds / radiation effects
  • Equipment Design
  • Equipment Failure Analysis
  • Female
  • Gamma Cameras*
  • Humans
  • Male
  • Middle Aged
  • Phantoms, Imaging
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Stroke Volume*
  • Tellurium / radiation effects
  • Tomography, Emission-Computed, Single-Photon / instrumentation*
  • Transducers
  • Ventricular Dysfunction, Left
  • Zinc Compounds / radiation effects


  • Cadmium Compounds
  • Zinc Compounds
  • Tellurium
  • cadmium telluride