Exosomal Protein Deficiencies: How Abnormal RNA Metabolism Results in Childhood-Onset Neurological Diseases

J Neuromuscul Dis. 2015;2(Suppl 2):S31-S37. doi: 10.3233/JND-150086. Epub 2015 Jul 22.

Abstract

Defects of RNA metabolism have been increasingly identified in various forms of inherited neurological diseases. Recently, abnormal RNA degradation due to mutations in human exosome subunit genes has been shown to cause complex childhood onset neurological presentations including spinal muscular atrophy, pontocerebellar hypoplasia and myelination deficiencies. This paper summarizes our current knowledge about the exosome in human neurological disease and provides some important insights into potential disease mechanisms.

Keywords: Exosome; RNA degradation; hypomyelination; pontocerebellar hypoplasia; spinal muscular atrophy.