Impact of night-shift work on the prevalence of erosive esophagitis in shipyard male workers

Int Arch Occup Environ Health. 2016 Aug;89(6):961-6. doi: 10.1007/s00420-016-1130-x. Epub 2016 Apr 29.


Purpose: Whether night-shift work is a risk factor for gastroesophageal reflux disease is controversial. The aim of this study was to investigate the association between night-shift work and other factors, and erosive esophagitis.

Methods: A cross-sectional study with 6040 male shipyard workers was performed. Esophagogastroduodenoscopic examination and a survey about night-shift work status, lifestyle, medical history, educational status, and marital status were conducted in all workers. The odds ratios of erosive esophagitis according to night-shift work status were calculated by using the logistic regression model.

Results: The prevalence of erosive esophagitis increased in the night-shift workers [odds ratio, 95 % confidence interval: 1.41 (1.03-1.94)]. According to multiple logistic regression models, night-shift work, obesity, smoking, and alcohol consumption of ≥140 g/week were significant risk factors for erosive esophagitis. By contrast, Helicobacter pylori infection was negatively associated with erosive esophagitis.

Conclusion: Night-shift work is suggested to be a risk factor for erosive esophagitis. Avoidance of night-shift work and lifestyle modification should be considered for prevention and management of gastroesophageal reflux disease.

Keywords: Erosive esophagitis; Male workers; Night-shift work; Prevalence.

MeSH terms

  • Adult
  • Chronobiology Disorders / complications*
  • Cross-Sectional Studies
  • Esophagitis / epidemiology*
  • Esophagitis / etiology*
  • Humans
  • Logistic Models
  • Male
  • Manufacturing Industry*
  • Middle Aged
  • Occupational Diseases / epidemiology*
  • Occupational Diseases / etiology*
  • Odds Ratio
  • Prevalence
  • Risk Factors
  • Ships
  • Work Schedule Tolerance / physiology