Efficacy of a sugar-free herbal lollipop for reducing salivary Streptococcus mutans levels: a randomized controlled trial

Clin Oral Investig. 2017 Apr;21(3):839-845. doi: 10.1007/s00784-016-1827-y. Epub 2016 Apr 30.

Abstract

Objective: The aim of our study was to evaluate the efficacy of an herbal lollipop containing licorice root extract on salivary Streptococcus mutans in caries-free and high-caries-risk children.

Materials and methods: The study was conducted in caries-free and high-caries-risk children, aged 5-11 years (n = 108). The groups were caries-free children (group A); high-caries-risk children whose dental treatment was completed before lollipop use (group B); and high-caries-risk children who did not comply with dental treatment (group C). The groups were divided into two subgroups: herbal (A-1, B-1, C-1) and placebo lollipops (A-2, B-2, C-2). Saliva samples were taken before dental treatment, before and after consuming lollipops, and at 3 months after consuming lollipops. The results were statistically analyzed with chi-squared test.

Results: Only in group C-1 (high-risk, using herbal lollipops) that significant reduction was observed in salivary S. mutans levels after lollipop use (p = 0.033), and only in the same group (C-1), there was significant difference between after lollipop use and third month levels (p = 0.006).

Conclusions: Herbal lollipops could be recommended to children with high-caries risk who do not comply with dental treatment in place of high-carbohydrate snacks.

Clinical relevance: The paper provides a perspective on using herbal products in high-risk children for reducing salivary S. mutans counts.

Keywords: Dental caries; Herbal therapy; Licorice; Saliva; Streptococcus mutans.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Candy*
  • Child
  • Child, Preschool
  • Dental Caries Susceptibility
  • Female
  • Glycyrrhiza*
  • Humans
  • Male
  • Plant Extracts / pharmacology*
  • Plant Roots
  • Saliva / microbiology*
  • Streptococcus mutans / drug effects*
  • Treatment Outcome

Substances

  • Plant Extracts