[Medical expert consensus in AH on the clinical use of triple fixed-dose antihypertensive therapy in Spain]

Hipertens Riesgo Vasc. 2016 Oct-Dec;33(4):133-144. doi: 10.1016/j.hipert.2016.03.001. Epub 2016 Apr 27.
[Article in Spanish]


Introduction: The opinion of experts (different specialties) on the triple fixed-dose antihypertensive therapy in clinical practice may differ.

Materials and methods: Online questionnaire with controversial aspects of the triple therapy answered by panel of experts in hypertension (HT) using two-round modified Delphi method.

Results: The questionnaire was completed by 158 experts: Internal Medicine (49), Nephrology (26), Cardiology (83). Consensus was reached (agreement) on 27/45 items (60%); 7 items showed differences statistically significant. Consensus was reached regarding: Predictive factors in the need for combination therapy and its efficacy vs. increasing the dose of a pretreatment, and advantage of triple therapy (prescription/adherence/cost/pressure control) vs. free combination.

Conclusions: This consensus provides an overview of the clinical use of triple therapy in moderate-severe and resistant/difficult to control HT.

Keywords: Antihipertensivos; Antihypertensive drugs; Arterial hypertension; Combinación de medicamentos; Drug combination; Hipertensión arterial.

MeSH terms

  • Advisory Committees / organization & administration
  • Antihypertensive Agents / therapeutic use*
  • Consensus*
  • Delphi Technique
  • Drug Therapy, Combination
  • Health Care Surveys
  • Humans
  • Hypertension / drug therapy*
  • Spain


  • Antihypertensive Agents