Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study

J Infect Dis. 2016 Aug 1;214(3):399-402. doi: 10.1093/infdis/jiw165. Epub 2016 Apr 29.

Abstract

The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.

Keywords: HIV-1 drug resistance; integrase; population viral load; prevalence; transmission of drug resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • Cohort Studies
  • Disease Transmission, Infectious*
  • Drug Resistance, Viral*
  • Drug Utilization
  • HIV / drug effects*
  • HIV / genetics*
  • HIV / isolation & purification
  • HIV Infections / drug therapy
  • HIV Infections / epidemiology
  • HIV Infections / transmission*
  • HIV Infections / virology
  • HIV Integrase / genetics*
  • HIV Integrase Inhibitors / therapeutic use
  • Humans
  • Prevalence
  • Switzerland / epidemiology

Substances

  • Anti-HIV Agents
  • HIV Integrase Inhibitors
  • HIV Integrase