Ameloblastic Fibrosarcoma of the Mandible Evolving From a Prior Ameloblastic Fibroma After Two Years: An Unusual Finding

Int J Surg Pathol. 2016 Oct;24(7):656-9. doi: 10.1177/1066896916646448. Epub 2016 Apr 28.


Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. The patient is currently under careful long-term follow-up and is free of disease. This article describes the clinical and radiographic features, histological characteristics, immunohistochemical findings, and surgical treatment of the tumor.

Keywords: ameloblastic fibroma; ameloblastic fibrosarcoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis
  • Cell Transformation, Neoplastic*
  • Disease Progression
  • Fibroma / diagnosis
  • Fibroma / pathology*
  • Fibrosarcoma / diagnosis
  • Fibrosarcoma / pathology*
  • Humans
  • Immunohistochemistry
  • Male
  • Mandibular Neoplasms / diagnosis
  • Mandibular Neoplasms / pathology*
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / pathology
  • Odontogenic Tumors / diagnosis
  • Odontogenic Tumors / pathology*


  • Biomarkers, Tumor