Patient Satisfaction With Collagenase

J Hand Surg Am. 2016 Jun;41(6):689-97. doi: 10.1016/j.jhsa.2016.03.003. Epub 2016 Apr 28.


Purpose: To establish patient satisfaction after collagenase clostridium histolyticum (CCH) injection.

Methods: In a cross-sectional study, 213 patients who had been treated for Dupuytren disease with CCH were reviewed between 37 and 1421 days after injection.

Results: A total of 73% of the patients were very satisfied or satisfied, and 21% were dissatisfied; 75% would probably or definitely have CCH again, whereas 17% probably or definitely would not. We found that satisfaction and willingness to undergo a second treatment decreased over time and had a negative relationship with recurrence. Dissatisfaction was greater in those with a poor initial outcome but not in those with an initial complication. Of 212 patients, 78 had previously experienced surgery for Dupuytren disease of whom 71% would prefer CCH to surgery and 15% the converse. Satisfaction shows a relationship with function as measured by both QuickDASH and the Southampton Dupuytren Scoring Scheme.

Conclusions: Patient satisfaction with CCH is generally high but deteriorates over time as the disease recurs. To manage patient expectation, this issue should be made explicit to patients in the consent process.

Clinical relevance: Overall satisfaction with CCH is high, with initial satisfaction rates especially good. Forewarning of complications and recurrence can help maintain satisfaction levels.

Keywords: Collagenase; collagenase clostridium histolyticum; complications; patient-related outcome measures; satisfaction.

MeSH terms

  • Cross-Sectional Studies
  • Dupuytren Contracture / diagnostic imaging
  • Dupuytren Contracture / drug therapy*
  • Female
  • Follow-Up Studies
  • Hand Strength*
  • Humans
  • Injections, Intralesional
  • Male
  • Microbial Collagenase / administration & dosage*
  • Patient Satisfaction / statistics & numerical data*
  • Recovery of Function
  • Self Report*
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Treatment Outcome


  • Microbial Collagenase