CMPF: A Biomarker for Type 2 Diabetes Mellitus Progression?

Trends Endocrinol Metab. 2016 Jul;27(7):439-440. doi: 10.1016/j.tem.2016.04.010. Epub 2016 Apr 27.

Abstract

The factors that precipitate the transition from insulin resistance to type 2 diabetes mellitus (T2DM) remain elusive. A recent study showed that circulating levels of the furan fatty acid (FA) metabolite 3-Carboxy-4-Methyl-5-Propyl-2-Furanopropanoic Acid (CMPF) increase in individuals who progress from prediabetes to T2DM. CMPF increases oxidative stress and impairs insulin granule maturation and secretion.

MeSH terms

  • Animals
  • Biomarkers / metabolism*
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / pathology
  • Furans / metabolism*
  • Humans
  • Insulin / metabolism
  • Oxidative Stress / physiology
  • Prediabetic State / metabolism*
  • Prediabetic State / pathology
  • Propionates / metabolism*

Substances

  • 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid
  • Biomarkers
  • Furans
  • Insulin
  • Propionates