Safety, efficacy, and tolerability of differential treatment to prevent and treat vaginal dryness and vulvovaginitis in diabetic women

Clin Exp Obstet Gynecol. 2016;43(2):198-202.


Background: Problems affecting the vaginal tract in diabetic women are very often neglected. The efficacy and safety of three gynecological treatments in diabetic women have been assessed.

Materials and methods: A single-blind randomized progressive trial on 48 diabetic women affected by vaginal dryness, dyspareunia, and recurrent Candida infections was carried out. The ICIQ Vaginal Symptoms (ICIQ-VS) questionnaire was administered.

Results: The analysis of the parameters of ICIQ-VS questionnaire among the three groups showed significant difference only for "dragging pain" (p = 0.0 19) and "soreness" (p = 0.028). In all groups and for all parameters of the questionnaire, improvement of symptoms was observed. In particular, in Group 1 for all symptoms a highly significant difference was observed, to support the already known benefits of the products and of the proposed combination. Significant improvement was also observed in Group 2.

Conclusions: The proposed treatment with DermoXEN® Ultracalming Special for diabetics and DermoXEN® Vitexyl vaginal gel exert effective moisturizing and soothing action. Indeed, the aforementioned products have been proven effective for the main gynecological problems of diabetic women.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Intravaginal
  • Adult
  • Candidiasis, Vulvovaginal / drug therapy
  • Candidiasis, Vulvovaginal / prevention & control*
  • Diabetes Complications / drug therapy
  • Diabetes Complications / prevention & control*
  • Diabetes Mellitus*
  • Drug Combinations
  • Dyspareunia / drug therapy
  • Dyspareunia / prevention & control*
  • Female
  • Glycerol / therapeutic use*
  • Humans
  • Hyaluronic Acid / therapeutic use*
  • Lactic Acid / therapeutic use*
  • Lipids / therapeutic use
  • Middle Aged
  • Pantothenic Acid / analogs & derivatives*
  • Pantothenic Acid / therapeutic use
  • Recurrence
  • Single-Blind Method
  • Vaginal Creams, Foams, and Jellies / therapeutic use
  • Viscosupplements / therapeutic use*
  • Vulvovaginitis / drug therapy
  • Vulvovaginitis / prevention & control
  • ortho-Aminobenzoates / therapeutic use*


  • Drug Combinations
  • Lipids
  • Replens
  • Vaginal Creams, Foams, and Jellies
  • Viscosupplements
  • ortho-Aminobenzoates
  • Pantothenic Acid
  • dexpanthenol
  • dihydroavenanthramide D
  • Lactic Acid
  • Hyaluronic Acid
  • Glycerol