Testosterone Deficiency and Sleep Apnea

Urol Clin North Am. 2016 May;43(2):233-7. doi: 10.1016/j.ucl.2016.01.012. Epub 2016 Mar 21.


Obstructive sleep apnea (OSA) is a common condition among middle-aged men and is often associated with reduced testosterone (T) levels. OSA can contribute to fatigue and sexual dysfunction in men. There is suggestion that T supplementation alters ventilatory responses, possibly through effects on central chemoreceptors. Traditionally, it has been recommended that T replacement therapy (TRT) be avoided in the presence of untreated severe sleep apnea. With OSA treatment, however, TRT may not only improve hypogonadism, but may also alleviate erectile/sexual dysfunction.

Keywords: Continuous positive airway pressure; Obstructive sleep apnea; Sexual dysfunction; Testosterone deficiency.

Publication types

  • Review

MeSH terms

  • Humans
  • Hypogonadism / physiopathology*
  • Male
  • Sexual Dysfunction, Physiological / physiopathology*
  • Sleep Apnea Syndromes / blood
  • Sleep Apnea Syndromes / drug therapy
  • Sleep Apnea Syndromes / physiopathology*
  • Testosterone / blood
  • Testosterone / deficiency*
  • Testosterone / therapeutic use


  • Testosterone