Fundus changes in (type II) mesangiocapillary glomerulonephritis simulating drusen: a histopathological report

Br J Ophthalmol. 1989 Apr;73(4):297-302. doi: 10.1136/bjo.73.4.297.


We report for the first time to our knowledge the histopathological findings in the eye of a patient with type II mesangiocapillary glomerulonephritis (dense deposit disease) in which a deposit of material morphologically very similar to that which is pathognomonic for the disease in the kidney was demonstrated in Bruch's membrane. The nature of the deposit in the renal lesion is unknown but is considered to represent a structural alteration secondary to a reaction with anticomplement antibody. Clinically the fundus appearance resembled that seen in drusen.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Basement Membrane / pathology
  • Choroid / pathology*
  • Fluorescein Angiography
  • Glomerulonephritis, Membranoproliferative / pathology*
  • Humans
  • Male