A Mitochondrion-Specific Photoactivatable Fluorescence Turn-On AIE-Based Bioprobe for Localization Super-Resolution Microscope

Adv Mater. 2016 Jul;28(25):5064-71. doi: 10.1002/adma.201505906. Epub 2016 May 2.


A novel mitochondrion-specific photo-activatable fluorescence turn-on bioprobe, named as o-TPE-ON+, is designed and readily prepared, operating through a new photoactivatable mechanism of photocyclodehydrogenation. This bioprobe exhibits unique photoactivation behavior in cells, and is applied to super-resolution imaging of mitochondrion and its dynamic investigation in both fixed and live cells under physiological conditions without any external additives.

Keywords: fluorescence turn-on; mitochondrion-specific; photoactivatable fluorophores; photocyclodehydrogenation; super-resolution imaging.

MeSH terms

  • Biosensing Techniques
  • Fluorescent Dyes
  • Microscopy, Fluorescence
  • Mitochondria*


  • Fluorescent Dyes