Acetylcholine produces stimulus-specific receptive field alterations in cat auditory cortex

R Metherate; N M Weinberger

doi:10.1016/0006-8993(89)90210-2

Acetylcholine produces stimulus-specific receptive field alterations in cat auditory cortex

Brain Res. 1989 Feb 20;480(1-2):372-7. doi: 10.1016/0006-8993(89)90210-2.

Authors

R Metherate¹, N M Weinberger

Affiliation

¹ Center for the Neurobiology of Learning and Memory, University of California at Irvine 92717.

PMID: 2713663
DOI: 10.1016/0006-8993(89)90210-2

Abstract

Frequency receptive fields (RFs) were determined before and after pairing iontophoretic administration of acetylcholine (ACh) with a repeated single-frequency stimulus in the auditory cortex of barbiturate-anesthetized cats. In 58% of the cells, the paired ACh + tone treatment produced subsequent alterations of frequency RFs. In half of these cases, the RF modifications were highly specific to the frequency that had been paired with ACh. Atropine antagonized the frequency-specific effects of ACh, suggesting that they were mediated via muscarinic cholinergic receptors.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Acetylcholine / pharmacology*
Acoustic Stimulation
Animals
Atropine / pharmacology
Auditory Cortex / drug effects
Auditory Cortex / physiology*
Cats
Electronic Data Processing
Evoked Potentials, Auditory / drug effects

Substances

Atropine
Acetylcholine

Grants and funding

NS08001/NS/NINDS NIH HHS/United States