Evidence for central phenomena participating in the changes of responses of ventrobasal thalamic neurons in arthritic rats

Brain Res. 1989 Apr 10;484(1-2):383-8. doi: 10.1016/0006-8993(89)90386-7.


In this study performed in the Freund's adjuvant-induced arthritic rat, a local injection of lidocaine in one hind paw strongly depressed the ventrobasal thalamic neuronal responses to mild stimulation of both ankles. In parallel, a behavioral study provided evidence for a bilateral hypoalgesia, tested by the vocalization threshold to paw pressure, after a unilateral anesthetic block. The involvement of central phenomena in the changes of neuronal responsivity described in this model of experimental pain is therefore suggested.

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Arthritis / physiopathology*
  • Epinephrine / pharmacology
  • Lidocaine / pharmacology
  • Male
  • Pain / physiopathology*
  • Rats
  • Rats, Inbred Strains
  • Thalamus / physiopathology*


  • Lidocaine
  • Epinephrine