Reciprocal interactions between circadian clocks and aging

Mamm Genome. 2016 Aug;27(7-8):332-40. doi: 10.1007/s00335-016-9639-6. Epub 2016 May 2.


Virtually, all biological processes in the body are modulated by an internal circadian clock which optimizes physiological and behavioral performance according to the changing demands of the external 24-h world. This circadian clock undergoes a number of age-related changes, at both the physiological and molecular levels. While these changes have been considered to be part of the normal aging process, there is increasing evidence that disruptions to the circadian system can substantially impact upon aging and these impacts will have clear health implications. Here we review the current data of how both the physiological and core molecular clocks change with age and how feedback from external cues may modulate the aging of the circadian system.

Publication types

  • Review

MeSH terms

  • Aging / genetics*
  • Aging / physiology
  • Circadian Clocks / genetics*
  • Circadian Clocks / physiology
  • Circadian Rhythm / genetics*
  • Circadian Rhythm / physiology
  • Gene Expression Regulation, Developmental / genetics
  • Humans