Future Targets in Endothelial Biology: Endothelial Cell to Mesenchymal Transition

Curr Drug Targets. 2016;17(15):1707-1713. doi: 10.2174/1389450117666160502151308.


Endothelial to mesenchymal transition (EndMT) is a poorly understood phenomenon that results in normal endothelial cells acquiring a mesenchymal phenotype. EndMT has been observed in a number of pathological conditions, from cancer to fibrosis to cardiovascular disease and the process itself may play an important mechanistic role in the development of these disease states.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / pathology*
  • Endothelial Cells / cytology*
  • Epithelial-Mesenchymal Transition
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Signal Transduction