Diagnosis of Lyme disease in the pediatric acute care setting

Curr Opin Pediatr. 2016 Jun;28(3):287-93. doi: 10.1097/MOP.0000000000000339.


Purpose of review: We review the current evidence concerning the diagnosis of Lyme disease in children for application in the acute care setting.

Recent findings: Recent studies suggest that Lyme disease incidence is substantially higher than previously described. Although efforts are ongoing to identify alternative testing strategies, two-tiered serologic testing remains the diagnostic standard in children with compatible clinical syndromes. Published clinical prediction rules can assist clinicians caring for children with potential Lyme disease.

Summary: Two-tiered serologic testing remains the mainstay of the diagnosis of Lyme disease. To minimize the risk of a false positive test, serologic testing should be limited to those children with symptoms compatible with Lyme disease with potential exposure to ticks from endemic regions.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • False Negative Reactions
  • False Positive Reactions
  • Humans
  • Incidence
  • Lyme Disease / diagnosis*
  • Lyme Disease / epidemiology
  • Pediatrics*
  • Practice Guidelines as Topic
  • Sensitivity and Specificity
  • Serologic Tests / methods*
  • Serologic Tests / trends
  • United States / epidemiology