A Review of Antiviral and Antifungal Use and Safety during Pregnancy

Pharmacotherapy. 2016 Jun;36(6):668-78. doi: 10.1002/phar.1764.


Antiviral and antifungal use in pregnancy presents challenges because of the paucity of clinical and safety data for many agents in these classes. If untreated, viral and fungal infections can have deleterious effects on both maternal and fetal health. Understanding the use and risks of these medications in pregnancy is vital to provide appropriate care. This article reviews the current literature for the use of antiviral and antifungals, the pharmacokinetics of these agents, and their safety in pregnancy.

Keywords: antifungals; antivirals; pregnancy.

Publication types

  • Review

MeSH terms

  • Antifungal Agents / adverse effects
  • Antifungal Agents / pharmacokinetics
  • Antifungal Agents / therapeutic use*
  • Antiviral Agents / adverse effects
  • Antiviral Agents / pharmacokinetics
  • Antiviral Agents / therapeutic use*
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*


  • Antifungal Agents
  • Antiviral Agents