Novel understanding of self-reactive T cells

Oncoimmunology. 2015 Aug 31;5(3):e1083672. doi: 10.1080/2162402X.2015.1083672. eCollection 2016 Mar.


In a recent issue of Immunity, Mark Davis and colleagues describe that thymic selection does not eliminate but prunes self-reactive T cell clones. Self-reactive T cells are a natural part of the T-cell repertoire and may be important in the fight against pathogens in addition to being important immune regulators.

Keywords: Anti-Tregs; CD8; IDO; PD-L1; self-reactive T cells; thymic selection.