Regulating the construction and demolition of the synaptonemal complex

Nat Struct Mol Biol. 2016 May 4;23(5):369-77. doi: 10.1038/nsmb.3208.


The synaptonemal complex (SC) is a meiosis-specific scaffold that links homologous chromosomes from end to end during meiotic prophase and is required for the formation of meiotic crossovers. Assembly of SC components is regulated by a combination of associated nonstructural proteins and post-translational modifications, such as SUMOylation, which together coordinate the timing between homologous chromosome pairing, double-strand-break formation and recombination. In addition, transcriptional and translational control mechanisms ensure the timely disassembly of the SC after crossover resolution and before chromosome segregation at anaphase I.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Pairing
  • Chromosome Segregation
  • Humans
  • Meiosis*
  • Protein Processing, Post-Translational
  • Synaptonemal Complex / chemistry
  • Synaptonemal Complex / genetics
  • Synaptonemal Complex / metabolism*
  • Synaptonemal Complex / ultrastructure